New research has shown that the non-hallucinogenic components of cannabis could act as effective anti-cancer agents.
The anti-cancer properties of tetrahydrocannabinol (THC), the primary hallucinogenic component of cannabis, has been recognised for many years, but research into similar cannabis-derived compounds, known as cannabinoids, has been limited.
The study was carried out by a team at St George’s, University of London. It has been published in the journal Anticancer Research.
The team, led by Dr Wai Liu and colleagues carried out laboratory investigations using a number of cannabinoids, either alone or in combination with each other, to measure their anti-cancer actions in relation to leukaemia.
Of six cannabinoids studied, each demonstrated anti-cancer properties as effective as those seen in THC. Importantly, they had an increased effect on cancer cells when combined with each other.
Dr Liu said: “This study is a critical step in unpicking the mysteries of cannabis as a source of medicine. The cannabinoids examined have minimal, if any, hallucinogenic side effects, and their properties as anti-cancer agents are promising.
“These agents are able to interfere with the development of cancerous cells, stopping them in their tracks and preventing them from growing. In some cases, by using specific dosage patterns, they can destroy cancer cells on their own.
“Used in combination with existing treatment, we could discover some highly effective strategies for tackling cancer. Significantly, these compounds are inexpensive to produce and making better use of their unique properties could result in much more cost effective anti-cancer drugs in future.”
This latest research is part of a growing portfolio of studies into the medicinal properties of cannabis by the research team at St George’s. The next step will be to examine in the laboratory these compounds in combination with existing anti-cancer treatments and study treatment schedules to identify strategies that will maximise their efficacy.
The study examined two forms of cannabidiol (CBD), two forms of cannabigerol (CBG) and two forms of cannabigevarin (CBGV). These represent the most common cannabinoids found in the cannabis plant apart from THC.
Cannabis, also known as marijuana, is a plant from Central Asia that is grown in many parts of the world today. It is a controlled substance in the UK and is most commonly known as a recreational drug.
Cannabinoids are active chemicals in cannabis. They are also known more specifically as phytocannabinoids. There are 85 known cannabinoids in the cannabis plant. The main active cannabinoid in Cannabis is delta-9-tetrahydrocannabinol (THC).
The cannabis plant is known for its medicinal properties and has been used to relieve symptoms associated with cancer, HIV/AIDS, multiple sclerosis, anorexia, anxiety, depression, and numerous other illnesses and conditions.
Who Benefits from CBD?
With that said, and from our experience working with various physicians, there are certain types of patients who can benefit greatly from a CBD treatment as an adjunct to their medical routine: epileptics; some patients with severe auto immune disorders; multiple sclerosis patients; some Parkinson’s patients; patients with bi-polar disorder; and people with ADD come to mind.
CBD is particularly well suited as an anti-spasmodic and anti-anxiety remedy. It can also work in fighting pain and inflammation, though we find THC more consistently effective in this regard. Interestingly, THC and CBD utilize complementary and different pathways to fight inflammation. In general, CBD would be recommended for patients who cannot tolerate too much THC and respond sufficiently to CBD for their medical condition.
THC & CBD Synergy in Cancer Treatment
Many inquiries come from cancer patients who think that CBD is the active cancer-fighting component in cannabis – another myth. THC has been the go-to compound for helping cancer patients for many years. However, more recent research is showing that THC doesn’t act alone. CBD, while having anti-cancer properties in its own right and working on different pathways than THC, boosts THC’s effectiveness by mitigating its undesirable effects, thus allowing for higher doses of THC to be administered for greater clinical efficacy and safety.